Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Van Veen, G.K. Bolhuis, Y.S. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. %PDF-1.4 AVICEL RC 581. Molecular weight: Not Applicable 1.5. Looking for FMC'searnings news? Micro Crystalline Cellulose. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Manufactured by: China . Alginates also function as actives in some anti-reflux products. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Chemical Formula: (C6H10O5)n 1.4. Avicel PH-101. : 160182 Date Approved: 05/25/2010 Revision No. 1. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . pH 6.0 to 8.0 . Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Microcrystalline Cellulose Market Forcast 2023 To 2028 : In-depth No. 1.3. This Microcrystalline Cellulose . In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. 4 0 obj %PDF-1.3 Millipore. endobj Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. However, if handling bulk powders, observance of appropriate safeguards is recommended. <> The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. >> Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Well-recognized product that can do it all. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. PDF PRODUCT OVERVIEW: Avicel PH-200 - Signet AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Cellulose microcrystalline CAS 9004-34-6 | 102331 - EMD Millipore Microcrystalline Cellulose Market Share, Trend, Statistics - 2031 Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. /MediaBox [0 0 612 792] SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. ( These grades have particle sizes ranging from <30 to approximately 200. MCC helps in the formation of spheres because of its . MSDS Ref. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. << The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. AVICEL RC 581 at Rs 140/kg | Pharmaceutical Excipients in - IndiaMART Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Battista, O. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Have an order or account question, find answers in our Online Support articles. Fmc | Sds Cellulose microcrystalline MSDS - 102331 - Merck endobj ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Microcrystalline Cellulose (MCC) Manufacturing | Pharmaceutical Grade J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P SDS - Safety Data Sheet. MATERIAL SAFETY DATA SHEET - Sevron GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Doses up to 30 g per day appear to be . : 5. <> Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Microcrystalline Cellulose NF. 1 0 obj q9;v80 List of Microcrystalline Cellulose Products and Manufacturers <> The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. The table below shows the most common physicochemical parameters of this raw material. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Avicel RC-591 & CL-611 - Description. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. G2W4de=u183KGH{ vQ#4:1\wc In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Micro Crystalline Cellulose - Accent Microcell Pvt. Ltd. Medium size standard MCC grade, suited for the majority of directly compressible actives. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. A family of polysaccharide products that allow distinctive drug delivery solutions. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Quantity: 1 700 kgs. >> stream In 1964 FMC, Corporation . gac74 [#B6`Wnw7 The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Product Name: Microcrystalline Cellulose 1.2. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. 408. Microcystalline cellulose (WHO Food Additives Series 8) : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . If you are already a ChemPoint customer then sign up for access to our online ordering website. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. SUBSTANCE IDENTIFICATION 1.1. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . The aqueous solution to barrier membrane coating. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. ES454445A1 - Procedimiento para preparar una crema lactica de buena con < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! %PDF-1.5 We are artists at heart and creators by nature. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. <> Product Name Cellulose microcrystalline. PDF Material Safety Data Sheet GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Watch Now. Avicel PC 611 (FMC Biopolymer) | CosmeticsAndToiletries.com The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. All rights reserved. These, in turn, are assembled into fibrils in the cell wall. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. xv}O2' H~KEe9>G/,:9\i cas:9032-51-3 msds CELLULOSE PAB. 3 0 obj {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. However, consumption of large quantities of the material may have a laxative effect. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Date Approved: 05/25/2010. Have an order or account question? PDF Nfpa 491 Hazardous Chemicals Data An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. <> Material safety data sheet - FMC Corporation. Molecular Weight null. EMCOCEL - JRS Pharma The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Molecular weight: Not Applicable 1.5. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Quick Links. >> Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) CAS 9004-34-6, pH 5 - 7.5. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Are you looking for information about products and services by region? Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. microcrystalline cellulose melting point 130. MATERIAL SAFETY DATA SHEET. Apply today! Microcrystalline cellulose (cas 9004-34-6) SDS(Safety Data Sheet) /MSDS Microcrystalline Cellulose MSDS - Newseed Chemical Co., Limited PharmaCentral 2021 . 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . MATERIAL SAFETY DATA SHEET Version: 1.0 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . 9,LL!z : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. B;vLZpHU%ChUyD+[ FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. 4. Thus, Avicel contributes no or very few calories to the food system. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. PDF Safety Data Sheet - Accentuate Safety Data Sheet (SDS) Viewer. Substance Information - ECHA - Europa Some substance identifiers may have been claimed confidential, or may . LOT #: Available upon request. % The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. q9;v80q>jZ PDF Safety Data Sheet - Fmc A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. However, it yields non-digestible fibre. Microcrystalline Cellulose / Avicel PH-102. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. } !1AQa"q2#BR$3br The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. : 9004-34-6 Date Approved: 01/31/2008 . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. X\o^ Microcrystalline Cellulose - an overview | ScienceDirect Topics Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Microcrystalline Cellulose Side Effects. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. (Microcrystalline Cellulose Market Pr. Avicel PH-101 - Cellulose, Cellulose powder Avicel PH-200 microcrystalline cellulose NF, Ph. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Instead, they obtained a stable colloidal suspension. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. . HMo@9, U Q!R/1*;` No. FMC, JRS and Mingtai were estimated to hold for . : CL-611NF Date Approved: 01/13/2010. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! : 51395-75-6 Date Approved: 01/31/2008 Revision No. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Origin(s): Plant/Botanical. Buy Chemicals. endobj Browse Avicel PH-101 and related products at MilliporeSigma. (PDF) Commercial sources of "Avicel RC/CL" and its - ResearchGate Magazine: Material safety data sheet - FMC Corporation. Microcrystalline cellulose - Safety Data Sheet - ChemicalBook DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. We respect your privacy FMC Privacy Policy. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Synergies to simplify formulation challenges and reduce operational costs. Find answers in our support articles. Combines good flow and high compactibility. 0.25 - 0.37. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) BIOACCUMULATIVE POTENTIAL Safety Data Sheet for Cellulose microcrystalline 102331. PDF Pharma Solutions Avicel Co-Processed Product Selection Guide - DuPont vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? ). Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). No. Terms and Conditions Compliance Solutions Industries About 3E News & Events . The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Synonyms: Cellulose, Cellulose powder, Cotton linters. Avicel PC 611 (FMC Biopolymer) . CAS No. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Remove <> Microcrystalline Cellulose. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. . They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Heavy metals, % NMT 0.001 %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz }o]X4]. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples.